Technology
A new type of cancer therapy… CAR-T (Chimeric Antigen Receptor T-Cell Immunotherapy)
CAR-T therapy (Chimeric Antigen Receptor T-Cell Immunotherapy) is a new type of cancer therapy. T cells are taken from a patient’s blood and genetically engineered to express CAR and target tumor cells. After the CAR-T cells are infused back into the patient, they can recognize the surface antigens and kill tumor cells.
Control of the activity of CAR-T cells within tumours via focused ultrasound
National Library of Medicine. Published, Aug 2021
Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of centimetres. Here we show that the genetics and cellular functions of chimeric antigen receptor T cells (CAR-T cells) within tumours can be reversibly controlled by the heat generated by short pulses of focused ultrasound via a CAR cassette under the control of a promoter for the heat-shock protein…